Alteration of circulating miRNAs during myocardial infarction and association with lipid levels.

ABSTRACT:

Background

Increasing mortality and morbidity of coronary artery disease (CAD) highlight the emerging need for novel noninvasive markers such as circulating microRNAs (miRNAs).

Objective

To evaluate the circulating levels of miR-126-3p, miR-210-3p, let-7g-5p, and miR-326, and their associations with known contributors to CAD, in CAD subgroups.

Methods

We divided the cohort into 4 groups: non-CAD controls (≤30% stenosis; n = 55), and patients with stable angina pectoris (SAP; n = 48), unstable AP (UAP; n = 46), and myocardial infarction (MI; n = 36). The circulating levels of miR-126-3p, miR-210-3p, let-7g-5p, and miR-326 were determined using TaqMan Advanced miRNA Assays in serum specimens.

Results

Circulating miR-126-3p levels were lower in the MI and UAP grou

SUBMITTER: Ozuynuk-Ertugrul AS 

PROVIDER: S-EPMC11064099 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature