Selective 1,2-Hydroarylation(Alkenylation) of gem-Difluoroalkenes to Access (-CF₂ H) Motifs.

ABSTRACT: An emerging class of C-C coupling transformations that furnish drug-like building blocks involves catalytic hydrocarbonation of alkenes. However, despite notable advances in the field, hydrocarbon addition to gem-difluoroalkenes without additional electronic activation remains largely unsuccessful. This owes partly to poor reactivity and the propensity of difluoroalkenes to undergo defluorinative side reactions. Here, we report a nickel catalytic system that promotes efficient 1,2-selective hydroarylation and hydroalkenylation, suppressing defluorination and providing straightforward access to a diverse assortment of prized organofluorides bearing difluoromethyl-substituted carbon centers. In contrast to radical-based pathways and reactions triggered by hydrometallation via a nickel-hydrid

SUBMITTER: Lin LQH 

PROVIDER: S-EPMC11076007 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature