Human Milk Composition Is Associated with Maternal Body Mass Index in a Cross-Sectional, Untargeted Metabolomics Analysis of Human Milk from Guatemalan Mothers.

ABSTRACT:

Background

Maternal overweight and obesity has been associated with poor lactation performance including delayed lactogenesis and reduced duration. However, the effect on human milk composition is less well understood.

Objectives

We evaluated the relationship of maternal BMI on the human milk metabolome among Guatemalan mothers.

Methods

We used data from 75 Guatemalan mothers who participated in the Household Air Pollution Intervention Network trial. Maternal BMI was measured between 9 and <20 weeks of gestation. Milk samples were collected at a single time point using aseptic collection from one breast at 6 mo postpartum and analyzed using high-resolution mass spectrometry. A cross-sectional untargeted high-resolution metabolomics analysis was performed by coupling h

SUBMITTER: Sivalogan K 

PROVIDER: S-EPMC11079463 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature