Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.

Methods

Using electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS-Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structural

SUBMITTER: Baller EB 

PROVIDER: S-EPMC11101593 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature