Progressive accumulation of hyperinflammatory NKG2D^low NK cells in early childhood severe atopic dermatitis.

ABSTRACT: Atopic dermatitis (AD) is a chronic inflammatory skin disease that often precedes the development of food allergy, asthma, and allergic rhinitis. The prevailing paradigm holds that a reduced frequency and function of natural killer (NK) cell contributes to AD pathogenesis, yet the underlying mechanisms and contributions of NK cells to allergic comorbidities remain ill-defined. Here, analysis of circulating NK cells in a longitudinal early life cohort of children with AD revealed a progressive accumulation of NK cells with low expression of the activating receptor NKG2D, which was linked to more severe AD and sensitivity to allergens. This was most notable in children co-sensitized to food and aeroallergens, a risk factor for development of asthma. Individual-level longitudinal analysis in

SUBMITTER: Ochayon DE 

PROVIDER: S-EPMC11107477 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature