Geographic variation of mutagenic exposures in kidney cancer genomes.

ABSTRACT: International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden¹. In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence². Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations. Here we sequenced 962 clear cell renal cell carcinomas from 11 countries with varying incidence. The somatic mutation profiles differed between countries. In Romania, Serbia and Thailand, mutational signature

SUBMITTER: Senkin S 

PROVIDER: S-EPMC11111402 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature