Follicular lymphoma regulatory T-cell origin and function.

ABSTRACT:

Introduction

Follicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment, including follicular helper T cells (Tfh). Although FL-Tfh key role is well-documented, the impact of their regulatory counterpart, the follicular regulatory T cell (Tfr) compartment, is still sparse.

Methods

The aim of this study was to characterize FL-Tfr phenotype by cytometry, gene expression profile, FL-Tfr origin by transcriptomic analysis, and functionality by in vitro assays.

Results

CD4⁺CXCR5⁺CD25^hiICOS⁺ FL-Tfr displayed a regulatory program that is close to classi

SUBMITTER: Rodriguez S 

PROVIDER: S-EPMC11116630 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature