Virological evaluation of natural and modified attapulgite against porcine epidemic diarrhoea virus.

ABSTRACT:

Background

The Porcine Epidemic Diarrhea Virus (PEDV) has caused significant economic losses in the global swine industry. As a potential drug for treating diarrhea, the antiviral properties of attapulgite deserve further study.

Methods

In this study, various methods such as RT-qPCR, Western blot, viral titer assay, Cytopathic Effect, immunofluorescence analysis and transmission electron microscopy were used to detect the antiviral activity of attapulgite and to assess its inhibitory effect on PEDV.

Results

When exposed to the same amount of virus, there was a significant decrease in the expression of the S protein, resulting in a viral titer reduction from 10^-5.613 TCID₅₀/mL to 10^-2.90 TCID₅₀/mL, which represents a decrease

SUBMITTER: Wang T 

PROVIDER: S-EPMC11137985 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature