A new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform.

ABSTRACT: To accurately phenocopy human biology in vitro, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards three-dimensional (3D) and/or multicellular culture techniques. While these culture innovations are becoming more commonplace, there is a growing body of research that illustrates the benefits and even necessity of recapitulating the dynamic flow of nutrients, gas, waste exchange and tissue interactions that occur in vivo. However, cost and engineering complexity are two main factors that hinder the adoption of these technologies and incorporation into standard laboratory workflows. We developed LATTICE, a plug-and-play microfluidic platform able to house up to eight large tissue or organ models that c

SUBMITTER: Campo H 

PROVIDER: S-EPMC11181516 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature