The effect of Mycobacterium tuberculosis treatment on thrombelastography-assessed haemostasis: a prospective cohort study.

ABSTRACT:

Background and objective

Tuberculosis disease (TB) and tuberculosis infection (TBI) have been associated with increased risk of cardiovascular disease which may be connected to infection-related haemostatic changes. It is unknown if treatment of Mycobacterium tuberculosis influences haemostasis. Here, we assessed if TB or TBI treatment affects thrombelastography (TEG)-assessed haemostasis.

Methods

Individuals with TB or TBI were included from a TB outpatient clinic in Copenhagen, Denmark. Patients treated with antithrombotic medication or systemic immunosuppressants were excluded. TEG analysis was performed before and after TB/TBI treatment using the TEG^®6s analyser to provide data on the reaction time of clot initiation (R) (min), the speed of clot formation (K)

SUBMITTER: Lorentsson HJN 

PROVIDER: S-EPMC11201340 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature