Divergent landscapes of A-to-I editing in postmortem and living human brain.
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ABSTRACT:
SUBMITTER: Rodriguez de Los Santos M
PROVIDER: S-EPMC11208617 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
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Divergent landscapes of A-to-I editing in postmortem and living human brain.
Rodriguez de Los Santos Miguel M Kopell Brian H BH Buxbaum Grice Ariela A Ganesh Gauri G Yang Andy A Amini Pardis P Liharska Lora E LE Vornholt Eric E Fullard John F JF Dong Pengfei P Park Eric E Zipkowitz Sarah S Kaji Deepak A DA Thompson Ryan C RC Liu Donjing D Park You Jeong YJ Cheng Esther E Ziafat Kimia K Moya Emily E Fennessy Brian B Wilkins Lillian L Silk Hannah H Linares Lisa M LM Sullivan Brendan B Cohen Vanessa V Kota Prashant P Feng Claudia C Johnson Jessica S JS Rieder Marysia-Kolbe MK Scarpa Joseph J Nadkarni Girish N GN Wang Minghui M Zhang Bin B Sklar Pamela P Beckmann Noam D ND Schadt Eric E EE Roussos Panos P Charney Alexander W AW Breen Michael S MS
Nature communications 20240626 1
Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain. We challenge this assumption by comparing A-to-I editing between postmortem and living prefrontal cortical tissues. Major differences were found, with over 70,000 A-to-I sites showing higher editing levels in postmortem tissues. Increased A-to-I editing in pos ...[more]
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