Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia.

ABSTRACT:

Background

Enhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of chromatin remodeling in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) patients, and how it affects tumorigenesis and drug response. Our research focuses on investigating the role of enhancers in sustaining oncogenic transformation in children with BCP-ALL.

Methods

We used ATAC-seq to study the accessibility of chromatin in pediatric BCP-ALL at three different stages-onset, remission, and relapse. Using a combination of computational and experimental methods, we were able to analyze the accessibility landscape and focus on the most significant cis-regulatory sites. These sites were then functionally validated through the u

SUBMITTER: Corleone G 

PROVIDER: S-EPMC11210131 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature