Rhodomyrtone: a new anti-Staphylococcus aureus agent against resistant strains.

ABSTRACT:

Background

Rhodomyrtone is a novel plant-derived antibiotic compound originally isolated from Rhodomyrtus tomentosa leaf extract.

Objectives

To evaluate the activity of rhodomyrtone against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline.

Methods

Broth microdilution testing was used to determine the MICs and MBCs of rhodomyrtone, fosfomycin, vancomycin, daptomycin, linezolid and ceftaroline.

Results

ROM had an MIC₉₀ of 1 mg/L against 110 strains of MRSA from blood isolates as well as for all other isolates that were daptomycin resistant, VISA, VRSA or LRSA. The MBC₉₀ were 4 mg/L across all groups tested. Among all S. aureus groups teste

SUBMITTER: Saravolatz LD 

PROVIDER: S-EPMC11220652 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature