Association between tobacco smoke exposure and depression: the NHANES 2005-2018 and Mendelian randomization study.

ABSTRACT:

Objective

The relationship between tobacco smoke exposure (TSE) and depression is controversial. This study combined observational research and Mendelian randomization (MR) to explore the relationship of depression with both smoking status and cotinine levels.

Method

We collected relevant data from the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2018, and used weighted multifactorial logistic regression modelling to assess the correlation between TSE and depression, and assessed the causal relationship of depression with both smoking status and cotinine levels by MR.

Result

Current smokers had the highest risk of depression (OR 1.94; P < 0.01); there was a positive trend for correlation between daily smoking and depression (OR 1.66;

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11221044 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature