Life's essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study.

ABSTRACT:

Background

Evidence has shown that the individual metrics in Life's Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflammatory bowel disease (IBD). However, epidemiological evidence on the overall LE8 on IBD risk remains limited. We aimed to assess the longitudinal associations of LE8-defined CVH and the risks of IBD and its subtypes, ulcerative colitis (UC) and Crohn's disease (CD). We also tested whether genetic susceptibility could modify these associations.

Methods

A total of 260,836 participants from the UK Biobank were included. LE8 scores were determined by 8 metrics (physical activity, diet, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and bl

SUBMITTER: Yang H 

PROVIDER: S-EPMC11221134 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature