Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.

ABSTRACT:

Objective

To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared with standard care resuscitation in patients with hemorrhagic shock.

Background

Data demonstrating the safety and efficacy of early cold stored platelet transfusion are lacking following severe injury.

Methods

A phase 2, multicenter, randomized, open label, clinical trial was performed at 5 US trauma centers. Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures were enrolled and randomized. The intervention was the early transfusion of a single apheresis cold stored platelet unit, stored for up to 14 days versus standard care resuscitation. The primary outcome was feasibility and the principal clinical out

SUBMITTER: Sperry JL 

PROVIDER: S-EPMC11224567 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature