Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins.

ABSTRACT:

Background

Oligospermia is one of the most common reasons for male infertility which is troubling numerous couples of child-bearing age. This investigation scrutinizes the implications and mechanistic underpinnings of ursolic acid's effect on busulfan-induced oligospermia in mouse models.

Methods

A singular intraperitoneal injection of busulfan at a dosage of 30 mg/kg induced oligospermia. Two weeks subsequent to this induction, mice were subjected to various dosages of ursolic acid (10, 30, and 50 mg/kg body weight, respectively) on a daily basis for four consecutive weeks. Following this treatment period, a meticulous analysis of epididymal sperm parameters, encompassing concentration and motility, was conducted using a computer-assisted sperm analysis system. The histopat

SUBMITTER: Dong J 

PROVIDER: S-EPMC11229684 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature