Survival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study.

ABSTRACT:

Background

This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive breast cancer.

Methods

Women aged over 50 years with early invasive breast cancer diagnosed in England (2014-2019) who had breast surgery were identified from Cancer Registry data. Survival estimates were calculated from a flexible parametric survival model. A competing risk approach was used for breast cancer-specific survival (BCSS). Standardized survival probabilities and cumulative incidence functions for breast cancer death were calculated for each treatment by age.

Results

Among 101 654 women, 72.2% received BCS + RT and 27.8% re

SUBMITTER: Miller K 

PROVIDER: S-EPMC11229699 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature