Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants.

ABSTRACT:

Objective

To assess the effect of activated charcoal on the single-dose pharmacokinetics of mavacamten when administered 2 h or 6 h after mavacamten dosing.

Methods

In this open-label, randomized, parallel-group study, healthy adults were randomized into three groups to receive mavacamten 15 mg alone or mavacamten 15 mg plus activated charcoal 50 g administered either 2 h or 6 h after mavacamten dosing. Pharmacokinetic parameters were derived from plasma concentration-time data using noncompartmental methods.

Results

Of the 45 participants randomized, 37 completed the study. When activated charcoal was administered 2 h after mavacamten dosing, mavacamten absorption and exposure were reduced compared with when mavacamten was administered alone: the area under the conce

SUBMITTER: Merali S 

PROVIDER: S-EPMC11233281 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature