Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort.

ABSTRACT:

Background

Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort.

Methods

The GCKD study (N = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m² or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory dat

SUBMITTER: Stamellou E 

PROVIDER: S-EPMC11234294 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature