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A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence.

ABSTRACT: Candida auris is an emerging fungal pathogen responsible for health care-associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by C. auris and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. SCF1 is apparently specific to C. auris, and its expression mediates adhesion to inert and biological surfaces across isolates from all five clades. Unlike canonical fungal adhesins, which function through hydrophobic interactions, Scf1 relies on exposed cationic residues for surface association. SCF1 is required for C. auris biofilm formation, skin colonization, virulence in systemic infection, and colonization of inserted medical devices.

SUBMITTER: Santana DJ 

PROVIDER: S-EPMC11235122 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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A <i>Candida auris</i>-specific adhesin, Scf1<i>,</i> governs surface association, colonization, and virulence.

Santana Darian J DJ   Anku Juliet A E JAE   Zhao Guolei G   Zarnowski Robert R   Johnson Chad J CJ   Hautau Haley H   Visser Noelle D ND   Ibrahim Ashraf S AS   Andes David D   Nett Jeniel E JE   Singh Shakti S   O'Meara Teresa R TR  

Science (New York, N.Y.) 20230928 6665

<i>Candida auris</i> is an emerging fungal pathogen responsible for health care-associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by <i>C. auris</i> and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. <i>SCF1</i> is apparently specific to <i>C. auris</i>, and its expression mediates a  ...[more]

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