Insights into Actin Isoform-Specific Interactions with Myosin via Computational Analysis.

ABSTRACT: Actin, which plays a crucial role in cellular structure and function, interacts with various binding proteins, notably myosin. In mammals, actin is composed of six isoforms that exhibit high levels of sequence conservation and structural similarity overall. As a result, the selection of actin isoforms was considered unimportant in structural studies of their binding with myosin. However, recent high-resolution structural research discovered subtle structural differences in the N-terminus of actin isoforms, suggesting the possibility that each actin isoform may engage in specific interactions with myosin isoforms. In this study, we aimed to explore this possibility, particularly by understanding the influence of different actin isoforms on the interaction with myosin 7A. First, we compared

SUBMITTER: Yu CJ 

PROVIDER: S-EPMC11242942 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature