Vitamin B6, B12, and Folate's Influence on Neural Networks in the UK Biobank Cohort.

ABSTRACT:

Background

One-carbon metabolism coenzymes may influence brain aging in cognitively unimpaired adults.

Methods

Baseline data were used from the UK Biobank cohort. Estimated intake of vitamin B6, B12, and folate was regressed onto neural network functional connectivity in five resting-state neural networks. Linear mixed models tested coenzyme main effects and interactions with Alzheimer's disease (AD) risk factors.

Results

Increased B6 and B12 estimated intake were linked with less functional connectivity in most networks, including the posterior portion of the Default Mode Network. Conversely, higher folate was related to more connectivity in similar networks. AD family history modulated these associations: Increased estimated intake was positively associated with str

SUBMITTER: Li T 

PROVIDER: S-EPMC11243472 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature