Wnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review.

ABSTRACT:

Background

The interaction between muscle and bone is shown to be clinically important but the underlying mechanisms are largely unknown. The canonical Wnt/β-catenin signaling pathway is reported to be involved in muscle-bone crosstalk, but its detailed function remains unclear. This systematic review aims to investigate and elucidate the role of the Wnt/β-catenin signaling pathways in muscle-bone crosstalk.

Methods

We conducted a literature search on the Web of Science, PubMed, EBSCO and Embase with keywords "Wnt*", "bone*" and "muscle*". A systematic review was completed according to the guideline of preferred reporting items of systematic reviews and meta-analyses (PRISMA). Data synthesis included species (human, animal or cell type used), treatments involved, outcome mea

SUBMITTER: Lin W 

PROVIDER: S-EPMC11245956 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature