Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells. However, the causal relationship between peripheral blood immune cells and PSC remains insufficiently understood.

Methods

A bidirectional two-sample Mendelian randomization (MR) analysis was implemented to determine the causal effect between PBC and 731 immune cells. All datasets were extracted from a publicly available genetic database. The standard inverse variance weighted (IVW) method was selected as the main method for the causality analysis. Cochran's Q statistics and MR-Egger intercept were performed to evaluate heterogeneity and pleiotropy.

Results

In forward MR analysis, the expression rat

SUBMITTER: Wu P 

PROVIDER: S-EPMC11246896 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature