Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases.

ABSTRACT:

Introduction

We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K^trans) and BBB water exchange rate (k_w) varied in cerebral small vessel disease (cSVD) subtypes.

Methods

Thirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.

Results

In CADASIL, no difference in K^trans, but lower k_w was observed in multiple brain regions. In sporadic cSVD, no difference in k_w, but higher K^trans was found in the whole b

SUBMITTER: Ying Y 

PROVIDER: S-EPMC11247670 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature