Kidney phosphate wasting predicts poor outcome in polycystic kidney disease.

ABSTRACT:

Background

Patients with autosomal dominant polycystic kidney disease (ADPKD) have disproportionately high levels of fibroblast growth factor 23 (FGF-23) for their chronic kidney disease stage, however only a subgroup develops kidney phosphate wasting. We assessed factors associated with phosphate wasting and hypothesize that it identifies patients with more severe disease and predicts disease progression.

Methods

We included 604 patients with ADPKD from a multicenter prospective observational cohort (DIPAK; Developing Intervention Strategies to Halt Progression of Autosomal Dominant Polycystic Kidney Disease) in four university medical centers in the Netherlands. We measured parathyroid hormone (PTH) and total plasma FGF-23 levels, and calculated the ratio of tubular maximu

SUBMITTER: Xue L 

PROVIDER: S-EPMC11249971 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature