CircPTP4A2 knockdown suppresses NSCLC progression via regulating proliferation and activating anti-tumor immunity.

ABSTRACT:

Background

With a considerable variety of cancer subtypes, Non-small cell lung cancer (NSCLC) poses a substantial threat to public health, affecting a large number of individuals and resulting in a high mortality rate. Circular RNA (circRNA) has been applied in various diseases, including cancers. This study aims to investigate the clinial significance and functional role of circPTP4A2 in NSCLC.

Methods

The serum and tissue samples were collected for detecting circPTP4A2 expression in NSCLC using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Actinomycin D was used to treat NSCLC cells to detect circPTP4A2 stability. The CCK-8 and Transwell assays were utilized to assess the effects of circPTP4A2 in NSCLC cells. The ELISA assay and cytotoxicity analy

SUBMITTER: Wang C 

PROVIDER: S-EPMC11250973 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature