Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition in the United States, encompassing a wide spectrum of liver pathologies including steatosis, steatohepatitis, fibrosis, and cirrhosis. Despite its high prevalence, there are no medications currently approved by the Food and Drug Administration for the treatment of NAFLD. Recent work has suggested that NAFLD has a strong genetic component and identifying causative genes will improve our understanding of the molecular mechanisms contributing to NAFLD and yield targets for future therapeutic investigations. Oxidative stress is known to play an important role in NAFLD pathogenesis, yet the underlying mechanisms accounting for disturbances in redox status are not entirely understood. To better understand the re

SUBMITTER: Koch RL 

PROVIDER: S-EPMC11254179 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature