Integrative multi-omics analysis reveals cellular and molecular insights into primary Sjogren's syndrome.

ABSTRACT:

Objective

This study aims to comprehensively analyze genomic, transcriptomic, proteomic, and single-cell sequencing data to unravel the molecular basis of primary Sjögren's syndrome (pSS) and explore potential therapeutic targets.

Methods

Mendelian randomization and single-cell RNA sequencing were employed to analyze pSS data. Differentially expressed genes specific to different blood cell types were identified. Integration of multiomics data facilitated the exploration of genetic regulatory relationships.

Results

The analysis revealed distinct cell clusters representing various immune cell subsets. Several genes, including cathepsin S (CTSS) and glutathione S-transferase omega 1 (GSTO1), were identified as potential biomarkers and therapeutic targets for pSS. Diagnos

SUBMITTER: Tan Y 

PROVIDER: S-EPMC11255657 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature