Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids.

ABSTRACT: Realizing the full potential of organoids and assembloids to model neural development and disease will require improved methods for long-term, minimally invasive recording of electrical activity. Current technologies, such as patch clamp, penetrating microelectrodes, planar electrode arrays and substrate-attached flexible electrodes, do not allow chronic recording of organoids in suspension, which is necessary to preserve architecture. Inspired by kirigami art, we developed flexible electronics that transition from a two-dimensional to a three-dimensional basket-like configuration with either spiral or honeycomb patterns to accommodate the long-term culture of organoids in suspension. Here we show that this platform, named kirigami electronics (KiriE), integrates with and enables chronic r

SUBMITTER: Yang X 

PROVIDER: S-EPMC11260907 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature