Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants.

ABSTRACT:

Background

Respiratory syncytial virus (RSV)-associated lower respiratory tract infection contributes significantly to morbidity/mortality worldwide in low birthweight (LBW) infants (<2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies to LBW infants. We aimed to evaluate naturally acquired RSV anti-prefusion F protein (anti-preF) antibody transfer in pregnancies with LBW versus normal birthweight (NBW) infants.

Methods

In this cohort study conducted among pregnant individuals and their infants, we tested paired maternal and singleton infant cord samples for RSV anti-preF IgG via an electrochemiluminescence immunoassay, using linear regression to evaluate associations between LBW and anti-preF IgG. Covariates included s

SUBMITTER: Kachikis AB 

PROVIDER: S-EPMC11261662 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature