Subclinical rejection and allograft survival in kidney transplantation: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Subclinical rejection (SCR) refers to the presence of acute rejection without accompanying kidney allograft dysfunction. The impact of SCR on long-term graft survival remains a subject of ongoing debate.

Methods and analysis

We will perform a systematic search of databases including MEDLINE, Embase and Cochrane Central, from January 1995 to November 2023. We will include English-language studies involving adult kidney transplant patients who investigated SCR. We will exclude studies focused on 'for-cause' biopsies. Both title, abstract screening and full-text screening will be performed by two or more reviewers. The primary outcome of this study will be death-censored allograft loss. The secondary outcome will include development of subsequent rejection. For tim

SUBMITTER: Kalaria AL 

PROVIDER: S-EPMC11261677 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature