Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis.

ABSTRACT:

Introduction

Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.

Methods

We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.

Results

Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), p = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), p < 0.001) in TBM patients.

Conclusions

The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.

SUBMITTER: Liu X 

PROVIDER: S-EPMC11264080 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature