Pan-Cancer Analysis Links Altered RNA m⁷G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival.

ABSTRACT:

Background

N7-methylguanosine (m⁷G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m⁷G modifications caused by aberrant expression of m⁷G writers contribute to cancer progression and result in worse patient survival in several human cancers. However, studies that systematically assess the frequency and clinical relevance of aberrant m⁷G writer expression in a pan-cancer cohort remain to be performed.

Aims

This study aims to systematically investigate the molecular alteration and clinical relevance of m⁷G methyltransferase in human cancers.

Methods

We analysed genome, transcriptome and clinical data from the Cancer Genome Atlas Research Network spanning 33 types of human cancers

SUBMITTER: Su A 

PROVIDER: S-EPMC11264101 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature