Anti-Mullerian Hormone and Cardiometabolic Disease in Women: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Higher age-specific circulating anti-Müllerian hormone (AMH) levels have been linked to a lower risk of cardiometabolic outcomes. However, whether AMH has a casual role in the etiology of these diseases is unknown. The objective of this study was therefore to explore if circulating AMH levels have a causal effect on risk of coronary artery disease (CAD), ischemic stroke and type 2 diabetes (T2D) in women, using a two-sample Mendelian randomization (MR) approach.

Methods

We used four single nucleotide polymorphisms (SNPs) from the most recent AMH GWAS meta-analysis as instrumental variables. Summary-level data for CAD (n = 149,752; 11,802 cases), ischemic stroke (n = 17,541; 4678 cases) and T2D (n = 464,389; 30,052 cases) were extracted from the UK Biobank, the Str

SUBMITTER: Verdiesen RMG 

PROVIDER: S-EPMC11266950 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature