Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.

ABSTRACT:

Objective

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise with the increasing obesity epidemic. Rezdiffra as an activator of a thyroid hormone receptor-beta is the only Food and Drug Administration approved therapy. As such, there is a critical need to improve our understanding of gene expression regulation and signaling transduction in MASLD to develop new therapies. Matrin-3 is a DNA- and RNA-binding protein involved in the pathogenesis of human diseases. Here we examined its previously uncharacterized role in limiting hepatic steatosis and stress response via the constitutive androstane receptor (CAR).

Methods

Matrin-3 floxed and liver-specific knockout mice were fed either a chow diet or 60 kcal% high-fat diet (HFD) fo

SUBMITTER: Cheng X 

PROVIDER: S-EPMC11267048 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature