A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine.

ABSTRACT:

Objective

This epigenomics sub-study embedded within a randomized controlled trial examined whether an evidenced-based behavioral intervention model that decreased stimulant use altered leukocyte DNA methylation (DNAm).

Methods

Sexual minority men with HIV who use methamphetamine were randomized to a five-session positive affect intervention (n = 32) or an attention-control condition (n = 21), both delivered during three months of contingency management for stimulant abstinence. All participants exhibited sustained HIV virologic control - an HIV viral load less than 40 copies/mL at baseline and six months post-randomization. The Illumina EPIC BeadChip measured leukocyte methylation of cytosine-phosphate-guanosine (CpG) sites mapping onto five a priori candidate genes of inte

SUBMITTER: Carrico AW 

PROVIDER: S-EPMC11269022 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature