Adenosine kinase protects against acetaminophen-induced acute liver injury by activating autophagy in hepatocytes.

ABSTRACT: Acute liver injury (ALI) is a common life-threatening condition with a high mortality rate due to liver disease-related death. However, current therapeutic interventions for ALI remain ineffective, and the development of effective novel therapies is urgently needed. Liver samples from patients with drug-induced ALI were collected to detect adenosine kinase (ADK) expression. Male C57BL/6 J mice, hepatocyte-specific ADK knockout (ADK^HKO) mice, and their controls (ADK^f/f) were exposed to acetaminophen (APAP) and other treatments to investigate the mechanisms of APAP-related ALI. ADK expression was significantly decreased in APAP-injured livers. Hepatocyte-specific ADK deficiency exacerbated APAP-induced ALI, while a gain-of-function approach delivering AAV-ADK, markedly

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11281981 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature