The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.

ABSTRACT: Periodontitis, delineated by the destruction of structures that support teeth, is predominantly propelled by intricate immune responses. Immunomodulatory treatments offer considerable promise for the management of this ailment; however, the modulation of the periodontal immune microenvironment to facilitate tissue regeneration presents a substantial biomedical challenge. Herein, our study investigates the role of Wilms' tumor 1-associating protein (WTAP), a critical m⁶A methyltransferase, in the immunomodulation of periodontitis and assesses its viability as a therapeutic target. We observed heightened expression of WTAP in macrophages extracted from gingival tissues impacted by periodontitis, with a strong association with M1 polarization. Via loss-of-function experiments, we d

SUBMITTER: Li Y 

PROVIDER: S-EPMC11286459 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature