GABA_A receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis.

ABSTRACT: GABA_A receptors (γ-aminobutyric acid-gated receptors type A; GABA_ARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl^-/HCO₃ ^- ion channels. They are assembled as heteropentamers from a family of subunits including: α (1-6), β(1-3), γ(1-3), δ, ε, π, θ and ρ(1-3). GABA_ARs together with the postsynaptic adhesion protein Neuroligin 2 (NL2) and many other pre- and post-synaptic proteins guide the initiation and functional maturation of inhibitory GABAergic synapses. This study examined how GABA_ARs and NL2 interact with each other to initiate the formation of synapses. Two functionally distinct GABA_AR subtypes, the

SUBMITTER: Sui Y 

PROVIDER: S-EPMC11295144 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature