Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.

ABSTRACT:

Background

Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10-20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the Lung Adenocarcinoma (LUAD) histological subtype in never-smokers is predominately found in young women of European, North American, and Asian descent. While the clinical presentation and tumor genomic profiles of smokers have been widely examined, never-smokers are usually underrepresented, especially those of a Latin American (LA) background. In this work, we characterize, for the first time, the difference in the genomic profiles betwee

SUBMITTER: Garrido J 

PROVIDER: S-EPMC11297669 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature