Oxidative fluorination with Selectfluor: A convenient procedure for preparing hypervalent iodine(V) fluorides.

ABSTRACT: The ability to investigate hypervalent iodine(V) fluorides has been limited primarily by their difficult preparation traditionally using harsh fluorinating reagents such as trifluoromethyl hypofluorite and bromine trifluoride. Here, we report a mild and efficient route using Selectfluor to deliver hypervalent iodine(V) fluorides in good isolated yields (72-90%). Stability studies revealed that bicyclic difluoro(aryl)-λ⁵-iodane 6 was much more stable in acetonitrile-d ₃ than in chloroform-d ₁, presumably due to acetonitrile coordinating to the iodine(V) centre and stabilising it via halogen bonding.

SUBMITTER: Dearman SMG 

PROVIDER: S-EPMC11301045 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature