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Involvement of posterior hypothalamic CaMKII-positive neurons in ADHD-like behaviors in mice.

ABSTRACT: This study explores the behavioral effects of modulating CaMKII-positive (CaMKII+) neurons in the posterior hypothalamus (PH). Utilizing a chemogenetic approach in mice, we discovered that the activation of CaMKII + neurons within the PH is associated with heightened locomotor activity, reduced social interaction, and impulsive behavior unrelated to anxiety or avoidance. These observed behaviors share a significant resemblance with characteristics commonly found in attention deficit and hyperactivity disorder (ADHD). Notably, treatment with clonidine, which is frequently prescribed for ADHD, effectively reduced impulsive behaviors in our mouse model. Our findings uncover the role of the PH that has not been previously explored and suggest a possible involvement of the PH in the manifestation of ADHD-like behaviors.

SUBMITTER: Lee C

PROVIDER: S-EPMC11302079 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Involvement of posterior hypothalamic CaMKII-positive neurons in ADHD-like behaviors in mice.

Lee Changwoo C Woo Changsu C Ma Gyeong Ryeong GR Choi Kyuhyun K Kang Shin Jung SJ Shin Ki Soon KS

Molecular brain 20240805 1

This study explores the behavioral effects of modulating CaMKII-positive (CaMKII+) neurons in the posterior hypothalamus (PH). Utilizing a chemogenetic approach in mice, we discovered that the activation of CaMKII + neurons within the PH is associated with heightened locomotor activity, reduced social interaction, and impulsive behavior unrelated to anxiety or avoidance. These observed behaviors share a significant resemblance with characteristics commonly found in attention deficit and hyperact ...[more]

PMID: 39103932

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