Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) is associated with increased risk of stroke and mortality. It has been reported that the process of atrial fibrosis was regulated by β-catenin in rats with AF. However, pathophysiological mechanisms of this process in human with AF remain unclear. This study aims to investigate the possible mechanisms of β-catenin in participating in the atrial fibrosis using human right atrial appendage (hRAA) tissues .

Methods

We compared the difference of β-catenin expression in hRAA tissues between the patients with AF and sinus rhythm (SR). The possible function of β-catenin in the development of AF was also explored in mice and primary cells.

Results

Firstly, the space between the membrane of the gap junctions of cardiomyocytes was wider in th

SUBMITTER: Bai Y 

PROVIDER: S-EPMC11302159 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature