VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma.

ABSTRACT:

Background

Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to low T-cell infiltration and minimal PD-L1 expression. Identifying the mechanisms driving low T-cell infiltration is crucial for developing more effective immunotherapies.

Methods

We utilize a syngeneic mouse model to investigate the tumor immune microenvironment of MB and compare our findings to transcriptomic and proteomic data from human MB.

Results

Flow cytometry reveals a notable presence of CD45^hi/CD11b^hi macrophage-like and CD45^int/CD11b^int microglia-like tumor-associated macrophages (T

SUBMITTER: Munoz Perez N 

PROVIDER: S-EPMC11312086 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature