Immune-enhancing neutrophils reprogrammed by subclinical low-dose endotoxin in cancer treatment.

ABSTRACT: Despite the re-emergence of the pioneering "Coley's toxin" concept in anti-cancer immune therapies highlighted by check-point inhibitors and CAR-T approaches, fundamental mechanisms responsible for the immune-enhancing efficacy of low-dose "Coley's toxin" remain poorly understood. This study examines the novel reprogramming of immune-enhancing neutrophils by super-low dose endotoxin conducive for anti-cancer therapies. Through integrated analyses including scRNAseq and functional characterizations, we examined the efficacy of reprogrammed neutrophils in treating experimental cancer. We observed that neutrophils trained by super-low dose endotoxin adopt a potent immune-enhancing phenotype characterized by CD177^loCD11b^loCD80^hiCD40^hiDectin2^hi</

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11319772 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature