Identification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions.

ABSTRACT:

Objective

To determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.

Methods

This was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initial conversion factors and those resulting after a 48-hour titration period were examined. Sedation and withdrawal scores were measured, and doses were titrated based on a standardized practice within the unit.

Results

A total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) enteral cl

SUBMITTER: Stroeder J 

PROVIDER: S-EPMC11321815 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature