Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures.

ABSTRACT: Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding, and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient's medical conditions. Despite numerous animal studies

SUBMITTER: Mihajlovic M 

PROVIDER: S-EPMC11324701 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature