Genome-Wide Association Study Meta-Analysis Uncovers Novel Genetic Variants Associated with Olfactory Dysfunction.

ABSTRACT:

Importance

Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in older adults; however, its genetic basis remains largely unknown.

Objective

To identify the genetic loci associated with olfactory dysfunction in the general population.

Design setting and partiicipants

This genome-wide association study meta-analysis (GWMA) included participants of European ancestry (N = 22,730) enrolled in four different large population-based studies, followed by a multi-ancestry GWMA including participants of African ancestry (N = 1,030). The data analysis was performed from March 2023 through June 2024.

Exposures

Genome-wide single nucleotide polymorphisms.

Main outcomes and meas

SUBMITTER: Imtiaz MA 

PROVIDER: S-EPMC11326328 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature